Retroperitoneal Non-functioning Paraganglioma: A Case Report

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya

2019, Vol: 7, Issue: 2

7 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Author Agreement Form

« Previous Article

Case Report

J Interdiscip Histopathol. 2013; 1(3): 168-171

doi: 10.5455/jihp.20130115114630

Retroperitoneal Non-functioning Paraganglioma: A Case Report

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya.

Cited by (2)

Abstract
Retroperitoneal paragangliomas are relatively rare endocrine tumours derived from the extra-adrenal paraganglia of the autonomic nervous system. They can be functional when they secrete catecholamines or non-functional. The diagnosis of a paraganglioma is infrequently made preoperatively unless the tumour is functional. In this paper, the authors report a new case of non-functional paraganglioma. A 54-year-old woman with a past medical history of viral hepatitis, presented with vague abdominal pain of five years' duration. On examination, no abdominal mass was palpable and her blood pressure was 100/60 mm Hg. Abdominal computed tomography scan demonstrated a well-defined hypervascular retroperitoneal mass of heterogeneous density in the left para-aortic region measuring 3cm in diameter. As paraganglioma was suspected preoperatively, serum and urine cathecholamine levels were performed and were within normal range. Complete surgical excision of this mass was performed. Histological examination of the surgical specimen coupled with immunohistochemical study was consistent with the diagnosis of pararganglioma. Retroperitoneal paragangliomas are most commonly benign with good prognosis, but can be locally invasive and metastasize as well. The possibility for malignant transformation of paragangliomas makes surgical excision the treatment of choice.

Key words: paraganglioma, retroperitoneal tumour, non-functioning, immunohistochemistry.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Faten Limaiem Articles by Saadia Bouraoui Articles by Sirine Bouslama Articles by Sana Ben Slama Articles by Ahlem Lahmar Articles by Sabeh Mzabi-Regaya
	on Google
	on Google Scholar
	Article Statistics
	Viewed: 6371 Downloaded: 921 Cited: 2

REFERENCES

Clements RH, Holzman MD, Blevins LS, Molpus K, Goldstein RE. Endoscopic retroperitoneal resection of a para-aortic paraganglioma: Report of a case and description of a technique. Surgery 1999; 126: 977-979. http://dx.doi.org/10.1016/S0039-6060(99)70043-7

http://dx.doi.org/10.1016/S0039-6060(99)70043-7

Wen J, Li HZ, Ji ZG, Mao QZ, Shi BB, Yan WG. A case of large silent extra-adrenal retroperitoneal paraganglioma resected laparoscopically. Chin Med Sci J 2010; 25: 61-64. http://dx.doi.org/10.1016/S1001-9294(10)60023-5

http://dx.doi.org/10.1016/S1001-9294(10)60023-5

Whalen RK, Althausen AF, Daniels GH. Extra-adrenal pheochromocytoma. J Urol 1992; 147:1–10. [Pubmed]    Glenner GG, Grimley PM. Tumors of the extra-adrenal paraganglioma system (including chemoreceptors). In: Atlas of Tumor Pathology, Fascicle 9, Armed Forces Institute of Pathology, Washington DC, USA, 1997.

Enzinger FM, Weiss SW. Soft Tissue Tumors, 2nd ed, Mosby, St Louis, USA, pp 836-840, 1988

Brantigan CO, Katase RY. Clinical and pathologic features of paragangliomas of the organ of Zuckerkandl. Surgery 1969; 65: 898-905. [Pubmed]

Kimura N, Capella C, De Krijger RR, Thompson LDR, Lam KY, Komminoth P, Tischler AS, Young WF. Pathology and Genetics of Tumours of Endocrine Organs, IARC Press, Lyon, Paris, pp164-165, 2004.

Neumann HP, Pawlu C, Peczkowska M, Bausch B, McWhinney SR, Muresan M, Buchta M, Franke G, Klisch J, Bley TA, Hoegerle S, Boedeker CC, Opocher G, Schipper J, Januszewicz A, Eng C. Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD and gene mutations. Journal of the American Medical Association 2004; 292: 943-951. http://dx.doi.org/10.1001/jama.292.8.943 [Pubmed]
http://dx.doi.org/10.1001/jama.292.8.943

Law NW, Alfano L. Non-functioning retroperitoneal paraganglioma. J R Soc Med 1987; 80:246-247. [Pubmed]    [PMC Free Fulltext]

Yang JH, Bae SJ, Park S, Park HK, Jung HS, Chung JH, Min YK, Lee MS, Kim KW, Lee MK. Bilateral pheochromocytoma associated with paraganglioma and papillary thyroid carcinoma: report of an unusual case. Endocrine Journal 2007; 54: 227-231. http://dx.doi.org/10.1507/endocrj.K06-068 [Pubmed]
http://dx.doi.org/10.1507/endocrj.K06-068

Elder EE, Elder G, Larsson C. Pheochromocytoma and functional paraganglioma syndrome: no longer the 10% tumor. Journal of Surgical Oncology 2005; 89: 193-201. http://dx.doi.org/10.1002/jso.20177 [Pubmed]
http://dx.doi.org/10.1002/jso.20177

Mhanna T, Pianta E, Bernard P, Hervieu V, Partensky C. Preaortic paraganglioma mimicking a hypervascular tumor of the pancreas. Hepato-Gastroenterology 2004; 51: 1198-1201. [Pubmed]

Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM. Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics 2003; 23: 29-43. http://dx.doi.org/10.1148/rg.231025050 [Pubmed]
http://dx.doi.org/10.1148/rg.231025050

Tonyukuk V, Emral R, Temizkan S, Sertçelik A, Erden I, Corapçioglu D. Patient with multiple paraganglioma treated with long acting somatostatin analogue. Endocrine Journal 2003; 50: 507-513. http://dx.doi.org/10.1507/endocrj.50.507 [Pubmed]
http://dx.doi.org/10.1507/endocrj.50.507

This Article Cited By the following articles

RETROPERITONEAL PARAGANGLIOMA: A CASE REPORT jemds 2016; 5(63): 4497.	1

Pancreatic paraganglioma - a rare and dangerous entity. Vascular anatomy and impact on management Journal of Surgical Case Reports 2014; 2014(7): rju074.	2

How to Cite this Article

Pubmed Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya. Retroperitoneal Non-functioning Paraganglioma: A Case Report. J Interdiscip Histopathol. 2013; 1(3): 168-171. doi:10.5455/jihp.20130115114630

Web Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya. Retroperitoneal Non-functioning Paraganglioma: A Case Report. http://www.ejmjih.com/?mno=31315 [Access: February 16, 2020]. doi:10.5455/jihp.20130115114630

AMA (American Medical Association) Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya. Retroperitoneal Non-functioning Paraganglioma: A Case Report. J Interdiscip Histopathol. 2013; 1(3): 168-171. doi:10.5455/jihp.20130115114630

Vancouver/ICMJE Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya. Retroperitoneal Non-functioning Paraganglioma: A Case Report. J Interdiscip Histopathol. (2013), [cited February 16, 2020]; 1(3): 168-171. doi:10.5455/jihp.20130115114630

Harvard Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya (2013) Retroperitoneal Non-functioning Paraganglioma: A Case Report. J Interdiscip Histopathol, 1 (3), 168-171. doi:10.5455/jihp.20130115114630

Turabian Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya. 2013. Retroperitoneal Non-functioning Paraganglioma: A Case Report. Journal of Interdisciplinary Histopathology, 1 (3), 168-171. doi:10.5455/jihp.20130115114630

Chicago Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya. "Retroperitoneal Non-functioning Paraganglioma: A Case Report." Journal of Interdisciplinary Histopathology 1 (2013), 168-171. doi:10.5455/jihp.20130115114630

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya (2013) Retroperitoneal Non-functioning Paraganglioma: A Case Report. Journal of Interdisciplinary Histopathology, 1 (3), 168-171. doi:10.5455/jihp.20130115114630

Contact Information

Your comments are very important to us

How to cite this article

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in Journal of Interdisciplinary Histopathology are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright © 2020 Journal of Interdisciplinary Histopathology All Rights Reserved. Subject to change without notice from or liability to Journal of Interdisciplinary Histopathology. For best results, please use Internet Explorer or Google Chrome	Contact Information Your comments are very important to us We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below. Email us at info[at]scopemed.com We will respond within 48 to 72 hours. Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.