Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan

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Case Report

J Interdiscip Histopathol. 2013; 1(2): 93-97

doi: 10.5455/jihp.20130121075815

Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan.

Abstract
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements, also known as “double hit” lymphomas (DHL), are rare neoplasms characterized by highly aggressive clinical behavior, complex karyotypes, and a spectrum of pathological features overlapping with Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Primary renal lymphoma (PRL) by definition is a renal lymphoma without evidence of systemic involvement. PRL is extremely rare with less than 100 cases of both Hodgkin disease and non-Hodgkin lymphoma reported in literature. Double hit lymphomas have extremely poor prognosis, and high resistance to intensive chemotherapy, including high-dose chemotherapy. We describe a very rare case of DHL arising in kidney as PRL in whom concurrent IGH-BCL2 and MYC rearrangements were detected.

Key words: Primary renal lymphoma, double hit lymphoma

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How to Cite this Article

Pubmed Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscip Histopathol. 2013; 1(2): 93-97. doi:10.5455/jihp.20130121075815

Web Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. http://www.ejmjih.com/?mno=31474 [Access: February 15, 2020]. doi:10.5455/jihp.20130121075815

AMA (American Medical Association) Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscip Histopathol. 2013; 1(2): 93-97. doi:10.5455/jihp.20130121075815

Vancouver/ICMJE Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscip Histopathol. (2013), [cited February 15, 2020]; 1(2): 93-97. doi:10.5455/jihp.20130121075815

Harvard Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan (2013) Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscip Histopathol, 1 (2), 93-97. doi:10.5455/jihp.20130121075815

Turabian Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan. 2013. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. Journal of Interdisciplinary Histopathology, 1 (2), 93-97. doi:10.5455/jihp.20130121075815

Chicago Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan. "Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report." Journal of Interdisciplinary Histopathology 1 (2013), 93-97. doi:10.5455/jihp.20130121075815

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan (2013) Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. Journal of Interdisciplinary Histopathology, 1 (2), 93-97. doi:10.5455/jihp.20130121075815

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