E-ISSN 2146-8362
 

Review Article 


Differential Expression of LMP2/Ī²1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors

Takuma Hayashi.

Abstract
Uterine leiomyosarcoma (Ut-LMS) develops more often in myometrium of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of Ut-LMS is not substantially correlated with hormonal conditions, and the risk factor(s) are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant tumor Ut-LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to examine risk factor(s) associated with Ut-LMS, to establish a clinical treatment method. The mice with a homozygous deficiency for proteasome subunit, low-molecular mass polypeptide (LMP)2/b1i spontaneously develop Ut-LMS, with a disease prevalence of ~40% by 14 months of age. In the recent study, we found LMP2/b1i expression to be absent in human Ut-LMS, but present in human uterine LMA. Moreover, LMP2/b1i is reported to negatively regulate human Ut-LMS tumorigenesis. Therefore, LMP2/b1i is a potential diagnostic-biomarker for human Ut-LMS, and may be a targeted-molecule for a new therapeutic approach.

Key words: LMP2, uterine leiomyosarcoma, uterine leiomyoma, biomarker


 
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REFERENCES
Zaloudek C, Hendrickson MR. Mesenchymal tumors of the uterus, in Kurman RJ.(ed): Blaustein`s Pathology of the Female Genital Tract (ed 5). New York, Springer-Verlag, 2002; 5: 561-578.

Wu TI, Chang TC, Hsueh S, Hsu KH, Chou HH, Huang HJ, Lai CH. Prognostic factors and impact of adjuvant chemotherapy for uterine leiomyosarcoma. Gynecol Onco. 2006; 100: 166-172. http://dx.doi.org/10.1016/j.ygyno.2005.08.010 [Pubmed]   
http://dx.doi.org/10.1016/j.ygyno.2005.08.010

Leitao MM, Soslow RA, Nonaka D, Olshen AB, Aghajanian C, Sabbatini P, Dupont J, Hensley M, Sonoda Y, Barakat RR, Anderson S. Tissue microarray immunohisto chemical expression of estrogen, progesterone, and androgen receptors in uterine leiomyomata and leiomyosarcoma. Cancer 2004; 101: 1455-1462. http://dx.doi.org/10.1002/cncr.20521 [Pubmed]   
http://dx.doi.org/10.1002/cncr.20521

Perez EA, Pusztai L, Van de Vijver M. Improving patient care through molecular diagnostics. Semin Oncol 2004; 31: 14-20. http://dx.doi.org/10.1053/j.seminoncol.2004.07.017 [Pubmed]   
http://dx.doi.org/10.1053/j.seminoncol.2004.07.017

http://www.cancer.gov/cancertopics/pdq/treatment/uterinesarcoma/HealthProfessional/page1#Section_87

http://cancer.gov/cancertopics/pdq/treatment/uterinesarcoma/HealthProfessional

Evans HL, Chawla SP, Simpson C, Finn KP. Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988; 62: 2239-2247. http://dx.doi.org/10.1002/1097-0142(19881115)62:10<2239::AID-CNCR2820621028>3.0.CO;2-Y

http://dx.doi.org/10.1002/1097-0142(19881115)62:10<2239::AID-CNCR2820621028>3.0.CO;2-Y

Kurman RJ. Pathology of the Female Genital Tract, 4th ed. New York, Springer-Verlag, 2001; 4: 499.

Tavassoli FA, Devilee P. World Health Organization Classification of Tumours: Pathology and Genetics, Pathology and Genetics of Tumours of the Breast and Female Genital Organs. In: Hendrickson MR, Tavassoli FA, Kempson RL, McCluggage WG, Haller U, Kubik-Huch RA (eds) Tumours of the Uterin Corpus: Mesenchymal tumours and related lesions, 4 th ed, IARC Press, Lyon, France, pp 233-244, 2003

Lin JF, Slomovitz BM. Uterine sarcoma. Curr Oncol Rep 2008; 10: 512-518. http://dx.doi.org/10.1007/s11912-008-0077-9 [Pubmed]   
http://dx.doi.org/10.1007/s11912-008-0077-9

Amant F, Coosemans A, Debiec-Rychter M, Timmerman D, Vergote I. Clinical management of uterine sarcomas. Lancet Oncol 2009; 10: 1188-1198. http://dx.doi.org/10.1016/S1470-2045(09)70226-8

http://dx.doi.org/10.1016/S1470-2045(09)70226-8

Miettinen M, Fetsch JF. Evaluation of biological potential of smooth muscle tumours. Histopathol 2006; 48: 97-105. http://dx.doi.org/10.1111/j.1365-2559.2005.02292.x [Pubmed]   
http://dx.doi.org/10.1111/j.1365-2559.2005.02292.x

Peters JM, Franke WW, Kleinschmidt JA. Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm. J Biol Chem 1994; 269: 7709–7718. [Pubmed]   

Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. "3". Molecular Cell Biology, 5th ed, W.H. Freeman and CO, New York, USA, pp 66–72, 2004.

Konstantinova IM, Tsimokha AS, Mittenberg AG. Role of proteasomes in cellular regulation. Intl Rev Cell Mol Biol 2008; 267: 59–124. http://dx.doi.org/10.1016/S1937-6448(08)00602-3

http://dx.doi.org/10.1016/S1937-6448(08)00602-3

Wang J, Maldonado MA. The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases. Cell Mol Immunol 2006; 3: 255–261. [Pubmed]   

Muchamuel T, Basler M, Aujay MA, Suzuki E, Kalim KW, Lauer C, Sylvain C, Ring ER, Shields J, Jiang J, Shwonek P, Parlati F, Demo SD, Bennett MK, Kirk CJ, Groettrup M. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nature Med 2009; 15: 781-788. http://dx.doi.org/10.1038/nm.1978 [Pubmed]   
http://dx.doi.org/10.1038/nm.1978

Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S. Altered peptidase and viral-specifi c T cell response in LMP2 mutant mice. Immunity 1994; 1: 533-541. http://dx.doi.org/10.1016/1074-7613(94)90043-4

http://dx.doi.org/10.1016/1074-7613(94)90043-4

Hayashi T, Faustman DL. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. Cancer Res 2002; 62: 24-27. [Pubmed]   

http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&id=MGI:2152729#refs

Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kanai Y, Shiozawa T, Tonegawa S, Konishi I. Molecular approach on uterine leiomyosarcoma: LMP2-deficient mice as an animal model of spontaneous uterine leiomyosarcoma. Sarcoma 2011: 476498. Epub 2011 Mar 8.

Hayashi T, Kobayashi Y, Kohsaka S, Sano K. mutation in the ATP-binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2. Oncogene 2006; 25: 4016-4026. http://dx.doi.org/10.1038/sj.onc.1209434 [Pubmed]   
http://dx.doi.org/10.1038/sj.onc.1209434

Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Nagase S, Ishiko O, Kanai Y, Yaegashi N, Aburatani H, Shiozawa T, Tonegawa S, Konishi I. Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy. Sci Rep 2011; 1:180| [DOI via Crossref]    http://dx.doi.org/10.1038/srep00180

http://dx.doi.org/10.1038/srep00180

Zhai YL, Kobayashi Y, Mori A, Orii A, Nikaido T, Konishi I, Fujii S. Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas. Intl J Gynecol Pathol 2004; 18: 20-28. http://dx.doi.org/10.1097/00004347-199901000-00004

http://dx.doi.org/10.1097/00004347-199901000-00004

Wang HX, Wang HM, Li QL, Judoson PL. Expression of proteasome subunits low molecular mass polypeptide (LMP) 2 and LMP7 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Biol Reprod 2004; 71: 1317-1324. http://dx.doi.org/10.1095/biolreprod.104.030213 [Pubmed]   
http://dx.doi.org/10.1095/biolreprod.104.030213

Wang HX, Wang HM, Lin HY, Yang Q, Zhang H, Tsang, BK, Zhu C. Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. J Cell Physiol 2006; 206: 616-623. http://dx.doi.org/10.1002/jcp.20508 [Pubmed]   
http://dx.doi.org/10.1002/jcp.20508

Fu JJ, Lin P, Lv XY, Yan XJ, Wang HX, Zhu C, Tsang BK, Yu, XG, Wang H. Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion. Placenta. 2009; 30: 305-312. http://dx.doi.org/10.1016/j.placenta.2009.01.005 [Pubmed]   
http://dx.doi.org/10.1016/j.placenta.2009.01.005

Hayashi T, Horiuchi A, Aburatani H, Yaegashi N, Tonegawa S, Konishi I. A potential diagnostic biomarker: Proteasome LMP2/ß1i-differential expression in human uterus neoplasm. Nature Precedings 2012; March 2: hdl:10101/npre.2012.7082.1.

Horiuchi A, Nikaido T, Ito K, Zhai Y, Orii A, Taniguchi S, Toki T, Fujii S. Reduced expression of calponin h1 in leiomyosarcoma of the uterus. Lab Invest 1998; 78: 839-846. [Pubmed]   

Horiuchi A, Nikaido T, Taniguchi S, Fujii S. Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma. J Natl Cancer Inst 1999; 91: 790-796. http://dx.doi.org/10.1093/jnci/91.9.790 [Pubmed]   
http://dx.doi.org/10.1093/jnci/91.9.790

Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Nagase S, Ishiko O, Kanai Y, Yaegashi N, Aburatani H, Shiozawa T, Tonegawa S, Konishi I. Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1. FEBS Letter 2012; 586: 1824-1831. http://dx.doi.org/10.1016/j.febslet.2012.05.029 [Pubmed]   
http://dx.doi.org/10.1016/j.febslet.2012.05.029

Zhai, YL., Nikaido, T., Shiozawa, T., Orii, A. & Fujii, S. Expression of cyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. Intl. J. Cancer 1999; 84: 224-250. http://dx.doi.org/10.1002/(SICI)1097-0215(19990621)84:3<244::AID-IJC8>3.0.CO;2-2

http://dx.doi.org/10.1002/(SICI)1097-0215(19990621)84:3<244::AID-IJC8>3.0.CO;2-2

Ip PP, Cheung AN, Clement PB. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol 2009; 33: 992-1005. http://dx.doi.org/10.1097/PAS.0b013e3181a02d1c [Pubmed]   
http://dx.doi.org/10.1097/PAS.0b013e3181a02d1c

Ip PP, Tse KY, Tam KF. Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol 2010; 17: 91-112. http://dx.doi.org/10.1097/PAP.0b013e3181cfb901 [Pubmed]   
http://dx.doi.org/10.1097/PAP.0b013e3181cfb901

Vajtai I, Sahli R, Kappeler A, Christ ER, Seiler RW. Leiomyomatoid angiomatous neuroendocrine tumor (LANT) of the pituitary: a distinctive biphasic neoplasm with primitive secretory phenotype and smooth muscle-rich stroma. Acta Neuropathol 2006; 111: 278-283. http://dx.doi.org/10.1007/s00401-006-0051-2 [Pubmed]   
http://dx.doi.org/10.1007/s00401-006-0051-2

Sakashita N, Yamada M, Nakagawa T, Yamasaki H, Takeya M. A leiomyomatoid angiomatous neuroendocrine tumor of the myometrium: case study with ultrastructural analysis. Hum Pathol 2008; 39: 788-792. http://dx.doi.org/10.1016/j.humpath.2007.09.017 [Pubmed]   
http://dx.doi.org/10.1016/j.humpath.2007.09.017

How to Cite this Article
Pubmed Style

Takuma Hayashi. Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors. J Interdiscip Histopathol. 2013; 1(3): 153-159. doi:10.5455/jihp.20130210114005


Web Style

Takuma Hayashi. Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors. http://www.ejmjih.com/?mno=31894 [Access: July 16, 2019]. doi:10.5455/jihp.20130210114005


AMA (American Medical Association) Style

Takuma Hayashi. Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors. J Interdiscip Histopathol. 2013; 1(3): 153-159. doi:10.5455/jihp.20130210114005



Vancouver/ICMJE Style

Takuma Hayashi. Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors. J Interdiscip Histopathol. (2013), [cited July 16, 2019]; 1(3): 153-159. doi:10.5455/jihp.20130210114005



Harvard Style

Takuma Hayashi (2013) Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors. J Interdiscip Histopathol, 1 (3), 153-159. doi:10.5455/jihp.20130210114005



Turabian Style

Takuma Hayashi. 2013. Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors. Journal of Interdisciplinary Histopathology, 1 (3), 153-159. doi:10.5455/jihp.20130210114005



Chicago Style

Takuma Hayashi. "Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors." Journal of Interdisciplinary Histopathology 1 (2013), 153-159. doi:10.5455/jihp.20130210114005



MLA (The Modern Language Association) Style

Takuma Hayashi. "Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors." Journal of Interdisciplinary Histopathology 1.3 (2013), 153-159. Print. doi:10.5455/jihp.20130210114005



APA (American Psychological Association) Style

Takuma Hayashi (2013) Differential Expression of LMP2/β1i: As A Potential Biomarker of Human Uterine Mesenchymal Tumors. Journal of Interdisciplinary Histopathology, 1 (3), 153-159. doi:10.5455/jihp.20130210114005





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