Histopathology of the Liver following Administration of Artesunate in Adult Wistar Rats

Abstract

Felix Monday Onyije, Josiah S Hart

In most of the developing countries especially in Africa antimalaria drugs are taken regularly either to treat or prevent malaria. Fifteen wistar rats of both sexes were randomly divided into 3 groups of 5 each and tested as follows: - Group O- control (water), Group A – 2mg/kg and Group B - 6mg/kg. The animals were sacrificed after the 7th day. There was no mortality caused by the drug but dizziness in the animals. In the group administered with 2mg/kg of oral artesunate there was no form of distortion in the tissue architecture of the liver, but in the group administered with 6mg/kg of artesunate, artesunate caused sinusoidal congestion, infiltration of inflammatory cells and there was loss of tissue architecture. Drugs are produce to combat illnesses but may turn out to be harmful when administered wrongly. In most of the developing countries especially in Africa antimalaria drugs are taken regularly either to treat or prevent malaria. They are taken such that one could even imaging if it is a food supplement.