Plasmablastic lymphoma: A report of 2 cases with review of literature

Abstract

Geetha Vasudevan, Brij Mohan Kumar Singh, Arijit Bishnu,Abhijat Kulshreshta

Plasmablastic lymphoma (PBL) is an aggressive subtype of non-Hodgkin lymphoma initially described in extra-nodal sites in an immunocompromised and later in immunocompetent patients. PBL remains a diagnostic challenge due to morphological overlap with various other entities and also due to similarities on immunohistochemistry with plasma cell myeloma. In spite of therapeutic advances, PBL remains an aggressive disease with high fatality rate. We describe 2 cases of this uncommon neoplasm; both in immunocompromised patients.