Miklós Bély
Department of Pathology, Hospital of the Order of the Brothers of Saint John of God in Budapest, Budapest, HungaryPublications
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Research Article
Apatite Rheumatism and Chondrocalcinosis are Different Stages of the Same Metabolic Disorder: A Clinicopathologic Study of 21 Patients with Clinically Diagnosed Apatite Rheumatism or Chondrocalcinosis
Author(s): Miklós Bély* and Ágnes Apáthy
Introduction: Apatite rheumatism and chondrocalcinosis are considered to be different metabolic diseases and distinct clinical entities, although the clinical symptoms are the same, the most commonly affected joints overlap, and the currently available treatment is similar. Original descriptions, interdisciplinary studies and excellent clinicopathology manuals also support this view, since the Hydroxy Apatite (HA) crystals are virtually not existing in conventionally stained tissue sections, while the Calcium Pyrophosphate Dehydrate (CPPD) crystals may be retained. The introduction of the non-staining technique by Bély and Apáthy opened a new era in the diagnosis of crystal induced diseases, allowing the analysis of cholesterol, HA, CPPD, Mono Sodium Urate monohydrate (MSU) crystals, and others in traditionally fixed, paraffine.. Read More»